Research Scientist - Song Lab

Site: The General Hospital Corporation

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

Job Summary

Summary
The Song Lab at Massachusetts General Hospital and Harvard Medical School investigates the molecular mechanisms underlying neurodegenerative diseases, including Alzheimer’s disease, ALS/FTD, and Huntington’s disease. Our research integrates mechanistic neurobiology, human iPSC-derived neuronal models, advanced imaging, proteomics, and emerging AI-enabled technologies to understand how disease-associated proteins disrupt neuronal function and to translate these discoveries into novel biomarkers and therapeutic strategies.

The successful candidate will join a highly collaborative and interdisciplinary research environment spanning basic and translational neuroscience, structural biology, and AI-driven protein design. A major focus of this position will be a collaborative project evaluating AI-assisted de novo protein designs targeting pathological forms of amyloid-β, tau, and TDP-43, with the goal of developing new tools for disease detection and therapeutic intervention.

Candidates with expertise in one or more of the following areas are particularly encouraged to apply: protein biochemistry, cellular and animal models of neurodegeneration, human tissue processing and analysis, advanced microscopy, and multi-omics approaches. Experience working across disciplines and an interest in translating mechanistic discoveries into biomarkers and therapeutics are highly valued.

In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.

Does this position require Patient Care? No

Essential Functions
-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
-Contributes to the design and execution of experiments and/or research projects.
-Exercises judgment in selecting methods and technologies to obtain results.
-May collaborate with external researchers and/or receive external project funding support.
-Presents results and prepares publications.
-May assist PI in the training and supervision of other staff.

 

Education Doctorate Related Field of Study required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required Knowledge, Skills and Abilities - Excellent research skills. - Demonstrated evidence of specific scientific competence in field. - Demonstrated broad knowledge of field. - Evidence of potential for scientific creativity and original though. - Able to exercise independent judgment and leadership. - Ability to contribute to publications.

 

$60,000-$96,000

 

Onsite

 

114 16th Street

 

40

 

Regular

 

Day (United States of America)

 

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

 

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